Lithium Hydroxide → Lithium 4-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}-4-oxobutanoate

HRID 1070498Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1070498
[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[Cl:24])[CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13](=[O:20])[CH2:14][CH2:15][C:16]([O:18]C)=[O:17])[CH2:8][CH2:7]1.[OH-].[Li+:26]>CO.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[Cl:24])[CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13](=[O:20])[CH2:14][CH2:15][C:16]([O-:18])=[O:17])[CH2:10][CH2:11]1.[Li+:26]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 22396186Methyl 4-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}-4-oxobutanoate

Produkt 1

HCID 23689283Lithium 4-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}-4-oxobutanoateAusbeute 96,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of methyl 4-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}-4-oxobutanoate (3.72 g) in methanol (30 ml) was added lithium hydroxide (0.41 g) in water (10 ml) which was stirred under nitrogen for 48 hours. The solvent was removed under reduced pressure, the residue was triturated with ether and filtered to leave lithium 4-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}-4-oxobutanoate (3.50 g).

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was triturated with ether
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-48fcba7667c54c0692e89fad0d5e2871
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903085B1

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