Water → 2,2-Dichloro-3,3,3-trifluoro-1-(2,6-dichloro-4-nitrophenyl)-1-propanol

HRID 1073366Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1073366
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[C:6]([Cl:13])[C:3]=1[CH:4]=[O:5].[C:14]([C:18]([Zn]Cl)([Cl:20])[Cl:19])([F:17])([F:16])[F:15].C(C(Cl)(Cl)Cl)(F)(F)F.O>CN(C=O)C.C1COCC1.[Zn]>[Cl:19][C:18]([Cl:20])([C:14]([F:17])([F:16])[F:15])[CH:4]([C:3]1[C:2]([Cl:1])=[CH:9][C:8]([N+:10]([O-:12])=[O:11])=[CH:7][C:6]=1[Cl:13])[OH:5]

Komponenten

8

Edukt 4

HCID 962WaterHCID 96351,1,1-Trichloro-2,2,2-trifluoroethaneHCID 218388352,6-Dichloro-4-nitrobenzaldehydeHCID 178506323HCID 178506323, Verbindung

Produkt 1

HCID 148485192,2-Dichloro-3,3,3-trifluoro-1-(2,6-dichloro-4-nitrophenyl)-1-propanol

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23994ZincKatalysatorHCID 6228DimethylformamideLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

3 g of 2,6-dichloro-4-nitro benzaldehyde were reacted, in 20 ml of anhydrous DMF under a nitrogen atmosphere, with CF3CCl2ZnCl prepared from 5 g of CF3CCl3 and 2.2 g of Zn in 10 ml of THF at 60° C. for 1 hour. The mixture was heated at 50° C. for 2 hours and at the end of the reaction it was poured into acidulated water and extracted repeatedly with ethyl ether.

Aufarbeitung

  1. additionwas poured
  2. extractionextracted repeatedly with ethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-74c3d48a7dcf426eb8066870b97680eb
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04968847

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