Cysteamine Hydrochloride → HCID 15592302, Verbindung

HRID 1075077

Reaktionsgleichung

Reaktionsgleichung von HRID 1075077
Cl.[NH2:2][CH2:3][CH2:4][SH:5].C[O-].[Na+].Cl[CH2:10][C:11]1[N:15]=[C:14]([CH3:16])[O:13][N:12]=1>CO>[CH3:16][C:14]1[O:13][N:12]=[C:11]([CH2:10][S:5][CH2:4][CH2:3][NH2:2])[N:15]=1

Komponenten

5

Edukt 3

HCID 9082Cysteamine HydrochlorideHCID 3021573-(Chloromethyl)-5-methyl-1,2,4-oxadiazoleHCID 10942334Sodium Methoxide

Produkt 1

HCID 15592302HCID 15592302, VerbindungAusbeute 121,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

Cysteamine hydrochloride (3.03 g; 26.7 mmoles) was added in several portions over a period of 10 minutes to a stirred solution of sodium methylate (2.89 g; 53.4 mmoles) in 50 ml of methanol at 0°. After stirring for 70 minutes at 0°, a solution of 3-chloromethyl-5-methyl-1,2,4-oxadiazole (3.54 g; 26.7 mmoles) in 15 ml of methanol was added dropwise over a period of 15 minutes, and the reaction mixture was allowed to stir at ambient temperature for 16 hours. The mixture was filtered, evaporated and redissolved in isopropyl alcohol, then filtered and evaporated under reduced pressure to give the title compound (5.64 g) as a yellow oil. The NMR spectrum (60 MHz) in CDCl3 gave the following resonances δ: 3.77 (s, 2H); 2.77 (m, 4H); 2.63 (s, 3H).

Aufarbeitung

  1. stirringto stir at ambient temperature for 16 hours
  2. filtrationThe mixture was filtered
  3. customevaporated
  4. dissolutionredissolved in isopropyl alcohol
  5. filtrationfiltered
  6. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bbce1a95f8ca40b4a134bbc7e1a36c13
Quelldatensatz
uspto-grants-1983_07
Patentnummer
US04394508

Verknüpfte Notizen

Wird geladen…