4-Toluenesulfonyl chloride → N-Benzyl-3,4-dimethoxyamphetamine

HRID 1075500

Reaktionsgleichung

Reaktionsgleichung von HRID 1075500
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12](O)[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C1(C)C=CC(S(Cl)(=O)=O)=CC=1.[CH2:26]([NH2:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([NH:33][CH:12]([CH2:11][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)[CH3:13])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Komponenten

4

Edukt 3

HCID 73974-Toluenesulfonyl chlorideHCID 7504BenzylamineHCID 891873,4-Dimethoxy-alpha-methylbenzeneethanol

Produkt 1

HCID 410200N-Benzyl-3,4-dimethoxyamphetamine

Versuchsvorschrift

The 1-(3,4-dimethoxyphenyl)-2-propanol obtained above was subjected to sulfonylation by p-toluenesulfonyl chloride and reacted with benzylamine to give N-benzyl-3,4-dimethoxyamphetamine. The resultant compound was converted into 3,4-dimethoxyamphetamine by hydrogenation decomposition under hydrogen atmosphere with 5% Pd-C.

Quellen und Nachweise

ORD-Eintrag
ord-028b640de99046ed98364198a9c82c25
Quelldatensatz
uspto-grants-1999_05
Patentnummer
US05902900

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