Dichloromethane → 6-Cyano-2,4-dimethyl-11-ethyl-11H-dipyrido[3,2-b:2',3'-e][1,4]diazepine

Trifluorornethanesulfonic anhydride (0.24 mL, 14 mmol) was added to a solution of 0.314 g (1.2 mmol) 5,11-dihydro-2,4-dimethyl-11-ethyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine-6-one in 15 mL of methylene chloride containing 0.25 mL (14 mmol) of diisopropylethylamine. The resulting mixture was refluxed under Ar for 3 hr. Ethyl acetate (~200 mL) was then added and the solution was washed three times with water and four times with brine. After drying (magnesium sulfate), the solution was concentrated in vacuo and the residue dried under high vacuum for 2 hr. The residue was dissolved in 20 mL of methylene chloride, and 0.23 g (14 mol) of tetraethylammonium cyanide was added. After stirring the resulting solution overnight at room temperature, the reaction mixture was concentrated in vacuo. The residue was dissolved in 100 mL of ethyl acetate, and the solution washed with water and brine, and then dried (magnesium sulfate). The solution was concentrated in vacuo and the residue was chromatographed over silica (eluted with 5% ethyl acetate/hexane). The resulting solid was crystallized from heptane to provide 33 mg of the title compound as red crystals, m.p. 154°-155° C.

1. temperatureThe resulting mixture was refluxed under Ar for 3 hr
2. washthe solution was washed three times with water and four times with brine
3. dry with materialAfter drying (magnesium sulfate)
4. concentrationthe solution was concentrated in vacuo
5. customthe residue dried under high vacuum for 2 hr
6. dissolutionThe residue was dissolved in 20 mL of methylene chloride
7. concentrationthe reaction mixture was concentrated in vacuo
8. dissolutionThe residue was dissolved in 100 mL of ethyl acetate
9. washthe solution washed with water and brine
10. dry with materialdried (magnesium sulfate)
11. concentrationThe solution was concentrated in vacuo
12. customthe residue was chromatographed over silica (eluted with 5% ethyl acetate/hexane)
13. customThe resulting solid was crystallized from heptane

ORD-Eintrag

ord-f186d8506f734239944b0dc1b10a8755

Quelldatensatz

uspto-grants-1996_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05550117