4'-Hydroxyacetophenone → 2-Bromo-1-(4-hydroxyphenyl)ethanone

HRID 10787

Reaktionsgleichung

Reaktionsgleichung von HRID 10787
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1)=[O:3].[Br:11]Br>O1CCOCC1>[Br:11][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)=[O:3]

Komponenten

4

Edukt 2

HCID 74694'-HydroxyacetophenoneHCID 24408Bromine

Produkt 1

HCID 49642-Bromo-1-(4-hydroxyphenyl)ethanoneAusbeute 44 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a solution of 4-hydroxyacetophenone (2.5 g, 18.3 mmol) (Aldrich) in dioxane (10 mL) was added dropwise a solution of bromine (3.22 g, 20.1 mmol) in dioxane (20 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was recrystalized from methanol to provide 2-bromo-1-(4-hydroxyphenyl)ethanone (1.73 g, 44% yield).

Aufarbeitung

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue was recrystalized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-1467451901b34110b095a0f9bc4d4385
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094896B2

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