Hydrochloric Acid → Methyl 3-oxo-4-phenylbutanoate

HRID 1080479

Reaktionsgleichung

Reaktionsgleichung von HRID 1080479
C[C:2]1(C)[O:9][C:7](=[O:8])[CH2:6][C:4](=[O:5])O1.N1C=CC=CC=1.[C:17]1([CH2:23]C(Cl)=O)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.Cl>C(Cl)Cl>[C:17]1([CH2:23][C:4](=[O:5])[CH2:6][C:7]([O:9][CH3:2])=[O:8])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 7679Phenylacetyl chlorideHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dione

Produkt 1

HCID 2760261Methyl 3-oxo-4-phenylbutanoateAusbeute 91,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In 70 ml of methylene chloride was dissolved 36.03 g (0.25 mol) of Meldrum's acid. Pyridine (38.17 g, 0.48 mol) was used as a base. To the solution was added dropwise 42.52 g (0.275 mol) of phenylacetyl chloride in an ice bath while stirring. After the reaction, ice-water and diluted hydrochloric acid were added to wash. Methylene chloride was evaporated, methanol was added, followed by refluxing, and the solvent was evaporated to give 44 g (91.7%) of methyl 4-phenyl-3-oxobutyrate.

Aufarbeitung

  1. additionwere added
  2. washto wash
  3. customMethylene chloride was evaporated
  4. additionmethanol was added
  5. temperatureby refluxing
  6. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-be201824b37642caa2578b52e8f996bd
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05581007

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