Sodium Iodide → 4,4-Diphenylbutyl iodide

HRID 1082134

Reaktionsgleichung

Reaktionsgleichung von HRID 1082134
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:9][CH2:10]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[I-:19]>CC(=O)CC>[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:9][CH2:10][I:19])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 5238Sodium IodideHCID 122234581,1-Diphenyl-4-bromobutane

Produkt 1

HCID 155128794,4-Diphenylbutyl iodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

A mixture of 1,1-diphenyl-4-bromobutane (2.5 g, 12 mmol) and NaI (11.9 g, 80 mmol) in 2-butanone (70 ml) was heated for 4 hours at reflux. The solvent was removed in vacuo and the residue was taken up in Et2O (100 ml). The organic layer was washed with aqueous Na2SO3 (10%) and with brine, dried (Na2SO4), and concentrated in vacuo. The oil was distilled under high vacuum to obtain the title compound, bp 150° C./0.1 mm.

Aufarbeitung

  1. temperaturewas heated for 4 hours
  2. temperatureat reflux
  3. customThe solvent was removed in vacuo
  4. washThe organic layer was washed with aqueous Na2SO3 (10%) and with brine
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated in vacuo
  7. distillationThe oil was distilled under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-351e46e6a7ba475f89a12f4ceab7e503
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05589501

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