Water → 4-(Trifluoromethoxy)benzenemethanol

HRID 1084788

Reaktionsgleichung

Reaktionsgleichung von HRID 1084788
[H-].[Al+3].[Li+].[H-].[H-].[H-].[F:7][C:8]([F:19])([F:18])[O:9][C:10]1[CH:17]=[CH:16][C:13]([C:14]#N)=[CH:12][CH:11]=1.[OH2:20].[OH-].[Na+]>C(OCC)C>[F:7][C:8]([F:19])([F:18])[O:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][OH:20])=[CH:12][CH:11]=1

Komponenten

6

Edukt 4

HCID 962Water2×HCID 14798Sodium HydroxideHCID 676214-(Trifluoromethoxy)benzonitrileHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 1371844-(Trifluoromethoxy)benzenemethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

A solution of lithium aluminium hydride in diethyl ether (1.0M, 69.4 ml) was added dropwise to a stirred solution of 4-(trifluoromethoxy)benzonitrile (6.0 g) in diethyl ether (120 ml) over 15 minutes. Water (2.66 ml), 10% sodium hydroxide solution (2.66 ml) and water (7.98 ml) were then added successively, dropwise. The precipitated solid was filtered off and washed with diethyl ether. The filtrate and washings were combined and evaporated under reduced pressure to give 4-(trifluoromethoxy)benzyl alcohol, N.M.R. in deuteriochloroform: δ2.3 (1H,s), 4.65 (2H,s), 7.2 (2H,d), 7.35 (2H,d).

Aufarbeitung

  1. filtrationThe precipitated solid was filtered off
  2. washwashed with diethyl ether
  3. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8a6c4f1d475c48e5b81e3b4d865e66ef
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05006543

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