Pyridine → 6-(4-acetoxypiperidino)-2(1H)-quinolinone

HRID 1085470Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1085470
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1.[C:19](OC(=O)C)(=[O:21])[CH3:20].N1C=CC=CC=1.C(=O)(O)[O-].[Na+]>O>[C:19]([O:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1)(=[O:21])[CH3:20]

Komponenten

6

Edukt 4

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 104669946-(4-Hydroxypiperidino)carbostyril

Produkt 1

HCID 200601526-(4-acetoxypiperidino)-2(1H)-quinolinone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 6-(4-hydroxypiperidino)carbostyril (0.25 g), acetic anhydride (0.4 g) and dry pyridine (4 mL) was heated at 100° C. for 3 hours. The reaction mixture was cooled and water (about 35 mL) and sodium bicarbonate (0.6 g) were added. The mixture was chilled in ice and stirred. The resulting white solid was removed by filtration, washed with water and dried to give 6-(4-acetoxypiperidino)-2(1H)-quinolinone. 1/4 hydrate (0.3 g); m.p. 245°-250° C.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. temperatureThe mixture was chilled in ice
  3. customThe resulting white solid was removed by filtration
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b80b82fe7d2a4a3ebf85b1138c3e9ab5
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05010088

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