Hydrochloric Acid → HCID 14456701, Verbindung

HRID 1087416Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1087416
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11](Br)[C:12]([OH:14])=O)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[NH2:16][C:17](N)=[S:18].Cl.S1(CCCC1)(=O)=[O:22]>O>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH:11]2[S:18][C:17](=[O:22])[NH:16][C:12]2=[O:14])=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2652713-(4-Acetylphenyl)-2-bromopropanoic acidHCID 2723790Thiourea

Produkt 1

HCID 14456701HCID 14456701, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 3-(4-acetylphenyl)-2-bromopropanoic acid (87 g, 0.32 mol, prepared according to Cleland, Org. Synth. vol. 51, p. 1, 1971), and thiourea (48.7 g,) 0.64 mol) in sulfolane (100 mL) was heated to 105°-110° C. for 5 hours. To this mixture was added a 2N HCl solution (162 mL) and the resulting solution was heated to 105°-110° C. overnight. After cooling and diluting with water, present title product was collected, washed with water and dried (75 g, 94%); mp 171°-172° C.

Aufarbeitung

  1. temperaturethe resulting solution was heated to 105°-110° C. overnight
  2. temperatureAfter cooling

Quellen und Nachweise

ORD-Eintrag
ord-e08da3d16dd04c448403bc5de407a67e
Quelldatensatz
uspto-grants-1991_07
Patentnummer
US05036079

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