Hydrochloric Acid → E-3-(3-phenoxyphenyl)-1-chloroprop-2-ene

HRID 1090367Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1090367
[O:1]([C:8]1[CH:9]=[C:10]([CH:14](O)[CH:15]=[CH2:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:18].O>C(OCC)C>[O:1]([C:8]1[CH:9]=[C:10](/[CH:14]=[CH:15]/[CH2:16][Cl:18])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 129613931-(3-Phenoxyphenyl)prop-2-en-1-ol

Produkt 1

HCID 19915310E-3-(3-phenoxyphenyl)-1-chloroprop-2-ene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

1-(3-Phenoxyphenyl)prop-2-en-1-ol (0.05 g) was dissolved in diethyl ether (2 cm3) which had been previously saturated with hydrogen chloride gas, and the solution was stirred at the ambient temperature for 2 hours. Water was added to the mixture and the products extracted into further diethyl ether. The combined ethereal layers were dried over anhydrous magnesium sulphate and the solvent evaporated under reduced pressure. The residual oil was purified by column chromatography on a silica gel support, eluted with hexane containing 5% by volume ethyl acetate, to give E-3-(3-phenoxyphenyl)-1-chloroprop-2-ene (0.03 g).

Aufarbeitung

  1. extractionthe products extracted into further diethyl ether
  2. dry with materialThe combined ethereal layers were dried over anhydrous magnesium sulphate
  3. customthe solvent evaporated under reduced pressure
  4. customThe residual oil was purified by column chromatography on a silica gel support
  5. washeluted with hexane containing 5% by volume ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-2663ca2928ab492ba5664d43d224f18e
Quelldatensatz
uspto-grants-1992_01
Patentnummer
US05081273

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