Acetic Anhydride → HCID 14770847, Verbindung

HRID 1090385Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1090385
[NH2:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([F:17])[CH:8]=2)[CH2:3]1.[C:18](OC(=O)C)(=[O:20])[CH3:19]>C(O)(=O)C>[C:18]([NH:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([F:17])[CH:8]=2)[CH2:3]1)(=[O:20])[CH3:19]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 14770846HCID 14770846, Verbindung

Produkt 1

HCID 14770847HCID 14770847, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 24.1 g (0.1 mol) of 4-[3(amino)cyclopentyl]-2,5-difluorobenzoic acid in a mixture of 50 ml of acetic anhydride and 100 ml of acetic acid was heated at reflux for 6 hours. The solvent was removed in vacuo and the residue triturated with water. The solid was removed by filtration, washed with water, and dried in vacuo to give 25.3 g of the title compound.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 6 hours
  3. customThe solvent was removed in vacuo
  4. customthe residue triturated with water
  5. customThe solid was removed by filtration
  6. washwashed with water
  7. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2ef869172edc42d28aeb8ccd1837d40f
Quelldatensatz
uspto-grants-1992_01
Patentnummer
US05081254

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