Acetic Acid → 4-Hydroxypiperidine-4-carboxamide
Reaktionsgleichung
CC(O)=O.C([N:12]1[CH2:17][CH2:16][C:15]([OH:21])([C:18]([NH2:20])=[O:19])[CH2:14][CH2:13]1)C1C=CC=CC=1>CO.[Pd]>[OH:21][C:15]1([C:18]([NH2:20])=[O:19])[CH2:16][CH2:17][NH:12][CH2:13][CH2:14]1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
Pd/C (150 mg) and HOAc (2 mL) are added to a solution of 1-benzyl-4-hydroxy-piperidine-4-carboxylic acid amide (2 g, 8.5 mmol) in MeOH. The mixture is shaken under H2 (40 psi) for 14 h. The catalyst is removed by filtration and the solvent is removed in vacuo to give the title product. 1H NMR (CD3OD) 2.96(m, 4H), 2.05(m, 2H), 1.49 (m, 2H).
Aufarbeitung
- customThe catalyst is removed by filtration
- customthe solvent is removed in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-c6cb701bec8848af80c888abadf3ec7a
- Quelldatensatz
- uspto-grants-2012_03
- Patentnummer
- US08129395B2
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