Formic Acid → HCID 86634878, Verbindung

HRID 1097072Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1097072
[C:1](OC(=O)C)(=[O:3])C.C(O)=O.[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:14][CH:13]=1>C(=O)(O)[O-].[Na+]>[CH3:22][O:21][C:19](=[O:20])[CH2:18][C:15]1[CH:14]=[CH:13][C:12]([NH:11][CH:1]=[O:3])=[CH:17][CH:16]=1

Komponenten

5

Edukt 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 2761030Methyl 2-(4-aminophenyl)acetate

Produkt 1

HCID 86634878HCID 86634878, VerbindungAusbeute 73,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 516892Sodium BicarbonateLösungsmittel

Versuchsvorschrift

A solution of acetic anhydride (14.3 mL, 151 mmol) and formic acid (22.8 mL, 605 mmol) was stirred at room temperature for 1 h. Methyl (4-aminophenyl)acetate (5.00 g, 30.3 mmol) was added and the resulting mixture was stirred overnight. Saturated aqueous sodium bicarbonate (10 mL) was added and the resulting mixture was extracted with DCM (2×10 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated under reduced pressure to give the title compound (4.31 g) as a yellow oil, which was used in the next reaction without further purification.

Aufarbeitung

  1. extractionthe resulting mixture was extracted with DCM (2×10 mL)
  2. dry with materialThe combined organic layers were dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-971908a6bd234306997619c47b0435cc
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08138345B2

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