Water → HCID 178513306, Verbindung

HRID 1097699Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1097699
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]#[N:8].C(=O)([O-])[O-].[K+].[K+].[OH2:15].Cl.[NH2:17]O>CCO>[OH:15][NH:8][C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[NH:17]

Komponenten

6

Edukt 4

HCID 962WaterHCID 7522Pyridine-2-carbonitrileHCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochloride

Produkt 1

HCID 178513306HCID 178513306, VerbindungAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a mixture of 2-pyridinecarbonitrile (3 g, 29 mmol) and potassium carbonate (4.1 g, 30 mmol) in EtOH (30 ml) was added water (15 ml) and, cautiously, hydroxylamine hydrochloride (2.9 g, 42 mmol) and then heated at reflux for 6 h, cooled and evaporated to dryness. The residue was treated with water (100 ml) and the suspended solid product filtered off, washed with water and dried to yield the title compound as a white solid (2.28 g, 57%).

Aufarbeitung

  1. temperatureat reflux for 6 h
  2. temperaturecooled
  3. customevaporated to dryness
  4. additionThe residue was treated with water (100 ml)
  5. filtrationthe suspended solid product filtered off
  6. washwashed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a94e094ee67548509da3f39dbe15a321
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143264B2

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