Methanamine, N-methoxy-, hydrochloride (1:1) → (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopentan-2-ylcarbamate

HRID 1098866

Reaktionsgleichung

Reaktionsgleichung von HRID 1098866
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:13][CH2:14][CH3:15])[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:17][NH:18][O:19][CH3:20].F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2C=CC=CC=2N=N1.C(N(CC)C(C)C)(C)C>CN(C=O)C.C(OCC)(=O)C.O>[CH3:20][O:19][N:18]([CH3:17])[C:10](=[O:12])[C@@H:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])[CH2:13][CH2:14][CH3:15]

Komponenten

8

Edukt 4

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 81531DiisopropylethylamineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 2733748(2S)-2-(((tert-butoxy)carbonyl)amino)pentanoic acid

Produkt 1

HCID 9992774(S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopentan-2-ylcarbamate

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Commercially available (2S)-2-[(tert-butoxycarbonyl)amino]pentanoic acid (1.0 g, 4.6 mmol) and N,O-dimethylhydroxylamine hydrochloride (0.47 g, 4.8 mmol) were dissolved in DMF (18 ml). O-benzotriazole-1-yl-N,N,N′,N′-tetramethyl-uronium hexafluorophosphate (1.92 g, 5.06 mmol) and N,N-diisopropylethylamine (2.47 ml, 14.5 mmol) were added. The reaction was stirred at r.t. over night. The reaction was poured into a mixture of water and ethyl acetate. The mixture was shaken, the layers separated and the water layer washed twice with ethyl acetate. The collected organic phase was washed with a small portion of water and dried over sodium sulphate. The solvent was removed under educed pressure and the crude product was purified by flash chromatography.

Aufarbeitung

  1. stirringThe mixture was shaken
  2. customthe layers separated
  3. washthe water layer washed twice with ethyl acetate
  4. washThe collected organic phase was washed with a small portion of water
  5. dry with materialdried over sodium sulphate
  6. customThe solvent was removed
  7. customthe crude product was purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-0db9bf0e087d48f891cbf993d7a9dc0c
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143290B2

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