Hydrochloric Acid → (7-Methoxy-1-naphthyl)(oxo)acetic acid

HRID 1099495

Reaktionsgleichung

Reaktionsgleichung von HRID 1099495
C1OCCOCCOCCOCCOCC[O:3]C1.[CH3:19][O:20][C:21]1[CH:31]=[CH:30][C:29]2[C:32]3[C:22]=1[C:23](=[O:34])[C:24](=[O:33])[C:25]=3[CH:26]=[CH:27][CH:28]=2.O.Cl>CS(C)=O>[CH3:19][O:20][C:21]1[CH:22]=[C:32]2[C:29]([CH:28]=[CH:27][CH:26]=[C:25]2[C:24](=[O:33])[C:23]([OH:34])=[O:3])=[CH:30][CH:31]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 2855718-Crown-6HCID 22502643-Methoxyacenaphthoquinone

Produkt 1

HCID 14462720(7-Methoxy-1-naphthyl)(oxo)acetic acidAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

In a reactor, 4 mg of 18-crown-6 ether and then 230 mg of NaNH2 are successively introduced into a suspension of 100 mg of 3-methoxyacenaphthoquinone in 1 ml of DMSO. The mixture is stirred for 30 minutes at ambient temperature. Water (2 ml) is then added, followed by 2N HCl solution (3 ml). After two extractions with ethyl acetate, the solvents are dried over Na2SO4 and then evaporated off to yield the title product in the form of a yellow solid in a yield of 88% and with a chemical purity of more than 94%.

Aufarbeitung

  1. extractionAfter two extractions with ethyl acetate
  2. dry with materialthe solvents are dried over Na2SO4
  3. customevaporated off

Quellen und Nachweise

ORD-Eintrag
ord-4a1196c80d5a47079f125b06fd9b6367
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143449B2

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