Succinic anhydride → (R/S)-1-(1-adamantyl)methyl-2-(2-carboxyethyl)carbonyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

HRID 1106933

Reaktionsgleichung

Reaktionsgleichung von HRID 1106933
[C:1]12([CH2:11][CH:12]3[C:17]4[NH:18][C:19]5[C:24]([C:16]=4[CH2:15][CH2:14][NH:13]3)=[CH:23][CH:22]=[CH:21][CH:20]=5)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[C:25]1(=[O:31])[O:30][C:28](=[O:29])[CH2:27][CH2:26]1>O1CCOCC1>[C:1]12([CH2:11][CH:12]3[C:17]4[NH:18][C:19]5[C:24]([C:16]=4[CH2:15][CH2:14][N:13]3[C:25]([CH2:26][CH2:27][C:28]([OH:30])=[O:29])=[O:31])=[CH:23][CH:22]=[CH:21][CH:20]=5)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Komponenten

4

Edukt 2

HCID 7922Succinic anhydrideHCID 53933490(R/S)-1-(1-adamantyl)methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

Produkt 1

HCID 53950661(R/S)-1-(1-adamantyl)methyl-2-(2-carboxyethyl)carbonyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of (R/S)-1-(1-adamantyl)methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole (640 mg, 2.0 mmol) and succinic anhydride (250 mg, 2.5 mmol) was stirred in dioxan (5 ml) at room temperature for 17 hours. The white precipiate which had formed was isolated by filtration, washed with dioxan and dried. (640 mg, 76%).

Aufarbeitung

  1. customThe white precipiate which had formed
  2. customwas isolated by filtration
  3. washwashed with dioxan
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0532127899f14e8aba970fd530a877ab
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06057311

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