2-Butene, 1-bromo- → Ethyl hydantoate

HRID 1111005Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1111005
ON=CC1C=CC([NH:10][C:11]([NH:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:12])=CC=1.C[O-].[Na+].C(Br)C=CC>O>[CH2:18]([O:17][C:15]([CH2:14][NH:13][C:11](=[O:12])[NH2:10])=[O:16])[CH3:19]

Komponenten

5

Edukt 3

HCID 1224142-Butene, 1-bromo-HCID 10942334Sodium MethoxideHCID 867443964-(hydroxyiminomethyl)phenyl-N'-ethoxycarbonylmethylurea

Produkt 1

HCID 222535Ethyl hydantoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of N-[4-(hydroxyiminomethyl)phenyl]-N'-ethoxycarbonylmethylurea in 25% methanolic sodium methoxide (1.0 equivalent) is treated at room temperature with 1.1 equivalent of crotyl bromide. The reaction mixture is stirred until the temperature falls to about 20° C. The reaction mixture is then poured into cold water and extracted with diethyl ether The ether solution is dried over MgSO4 and filtered, and the solvent is removed by rotary evaporator to yield the corresponding N-[4-crotyloxyiminomethyl)phenyl]-N'-ethoxycarbonylmethylurea.

Aufarbeitung

  1. customfalls to about 20° C
  2. extractionextracted with diethyl ether The ether solution
  3. dry with materialis dried over MgSO4
  4. filtrationfiltered
  5. customthe solvent is removed by rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-2f143d14ef1843ab9fe27bc5bb02b4dc
Quelldatensatz
uspto-grants-1990_12
Patentnummer
US04977272

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