2-Butene, 1-bromo- → N-[4-(1-crotyloxyiminoethyl)phenyl]-N'-n-propoxycarbonylmethylurea

HRID 1111020Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1111020
[OH:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([NH:14][CH2:15][C:16]([O:18][CH2:19][CH2:20][CH3:21])=[O:17])=[O:13])=[CH:7][CH:6]=1)[CH3:4].C[O-].[Na+].[CH2:25](Br)[CH:26]=[CH:27][CH3:28]>O>[CH2:25]([O:1][N:2]=[C:3]([C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12]([NH:14][CH2:15][C:16]([O:18][CH2:19][CH2:20][CH3:21])=[O:17])=[O:13])=[CH:9][CH:10]=1)[CH3:4])[CH:26]=[CH:27][CH3:28]

Komponenten

5

Edukt 3

HCID 1224142-Butene, 1-bromo-HCID 10942334Sodium MethoxideHCID 86742131N-[4-(1-hydroxyiminoethyl)phenyl]-N'-(n-propoxycarbonylmethyl)urea

Produkt 1

HCID 54368908N-[4-(1-crotyloxyiminoethyl)phenyl]-N'-n-propoxycarbonylmethylurea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of the N-[4-(1-hydroxyiminoethyl)phenyl]-N'-n-propoxycarbonylmethylurea in 25% methanolic sodium methoxide (1.0 equivalent) is treated at room temperature with 1.1 equivalent of crotyl bromide. The reaction mixture is stirred until the temperature falls to about 20° C. The reaction mixture is then poured into cold water and extracted with diethyl ether. The ether solution is dried over MgSO4 and filtered, and the solvent is removed by rotary evaporator to yield the product N-[4-(1-crotyloxyiminoethyl)phenyl]-N'-n-propoxycarbonylmethylurea.

Aufarbeitung

  1. customfalls to about 20° C
  2. extractionextracted with diethyl ether
  3. dry with materialThe ether solution is dried over MgSO4
  4. filtrationfiltered
  5. customthe solvent is removed by rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-87b9dbe3c42d4db1807b5fda61acc161
Quelldatensatz
uspto-grants-1990_12
Patentnummer
US04977272

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