Water → 2-p-Tolylbenzoxazole

HRID 1111088

Reaktionsgleichung

Reaktionsgleichung von HRID 1111088
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([CH:7]=[O:8])=[CH:3][CH:2]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1O.O.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Pb+4]>C1(C)C=CC=CC=1>[CH3:9][C:1]1[CH:6]=[CH:5][C:4]([C:7]2[O:8][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=2)=[CH:3][CH:2]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 58012-AminophenolHCID 77254-MethylbenzaldehydeHCID 178418268HCID 178418268, Verbindung

Produkt 1

HCID 700392-p-Tolylbenzoxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 120.2 g (1 mole) of 4-tolualdehyde and 109.1 g (1 mole) of 2-aminophenol in toluene is heated at reflux with azeotropic removal of water. After 20 hours at reflux, the reaction is cooled to room temperature, then 443.4 g (1 mole) of lead tetraacetate is added, and the mixture is stirred at room temperature for 20 hours. The solids are removed by filtration, and the filtrate is swirled with basic alumina. Removal of the solvent in vacuo affords the solid product which is then purified by recrystallization from ethanol.

Aufarbeitung

  1. temperatureAfter 20 hours at reflux
  2. customThe solids are removed by filtration
  3. customRemoval of the solvent in vacuo
  4. customaffords the solid product which
  5. customis then purified by recrystallization from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-7d9256f518ab4910a69dd2dc707f9056
Quelldatensatz
uspto-grants-1990_12
Patentnummer
US04978476

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