Ammonium formate → 2,2-Dimethyl-1,3-dioxan-5-amine

HRID 1111256Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1111256
[CH3:1][C:2]1([CH3:11])[O:7][CH2:6][CH:5]([N+:8]([O-])=O)[CH2:4][O:3]1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:1][C:2]1([CH3:11])[O:7][CH2:6][CH:5]([NH2:8])[CH2:4][O:3]1

Komponenten

5

Edukt 2

HCID 2723923Ammonium formateHCID 108774282,2-Dimethyl-5-nitro-1,3-dioxane

Produkt 1

HCID 117686082,2-Dimethyl-1,3-dioxan-5-amineAusbeute 70,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

220 mg 5% Pd/C was added to a solution of 500 mg 2,2-dimethyl-5-nitro-1,3-dioxane (3.1 mmoles) in 30 ml methanol. Ammonium formate (985 mg, 15.6 mmoles) was then added, and the mixture was refluxed for three hours. The reaction solution was then filtered, and the filtrate concentrated in vacuo to yield 286 mg 2,2-dimethyl-5-amino-1,3-dioxane (70% yield).

Aufarbeitung

  1. temperaturethe mixture was refluxed for three hours
  2. filtrationThe reaction solution was then filtered
  3. concentrationthe filtrate concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-42e6471954b34b13ba19fe924c582782
Quelldatensatz
uspto-grants-1990_12
Patentnummer
US04978793

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