Sodium Hydroxide → 3-Benzyl-4-chloroaniline

HRID 1111351Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1111351
[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl-].[Al+3].[Cl-].[Cl-].[NH2:11][C:12]1[CH:13]=[CH:14][C:15]([Cl:26])=[C:16]([CH:25]=1)[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=O.[OH-].[Na+]>CCOCC.O>[CH2:17]([C:16]1[CH:25]=[C:12]([CH:13]=[CH:14][C:15]=1[Cl:26])[NH2:11])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Komponenten

7

Edukt 4

HCID 14798Sodium HydroxideHCID 6451240Aluminum(III) ChlorideHCID 10489713(5-Amino-2-chlorophenyl)(phenyl)methanoneHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 221522153-Benzyl-4-chloroaniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 3283Diethyl EtherLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

6.8 g of lithium aluminium hydride, followed by 44.4 g of aluminium chloride and then 22 g of 5-amino-2-chlorobenzophenone dissolved in anhydrous ether are added in small amounts, under a nitrogen atmosphere, into 1000 ml of anhydrous ether which is cooled to 0° C. After stirring for 2 hours and under reflux, the excessive reagents are decomposed by very slowly adding 7 ml of 15% caustic soda and, finally, 21 ml of water. After filtering and washing the precipitate with 2×200 ml of ether, the organic phase is washed, dried over Na2SO4 and then evaporated to dryness under vacuum.

Aufarbeitung

  1. temperatureunder reflux
  2. filtrationAfter filtering
  3. washwashing the precipitate with 2×200 ml of ether
  4. washthe organic phase is washed
  5. dry with materialdried over Na2SO4
  6. customevaporated to dryness under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-040147399a444ba18ed3d5cb097da47b
Quelldatensatz
uspto-grants-1990_12
Patentnummer
US04980349

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