Cyclopropylamine → HCID 15581949, Verbindung
Reaktionsgleichung
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([NH2:10])=[S:9].[CH:11]1(N)[CH2:13][CH2:12]1>O>[CH:11]1([NH:10][C:8](=[S:9])[CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:13][CH2:12]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 7.6 g. (0.05 mole) of 2-(2-pyridyl)thioacetamide in a 40% aqueous solution of cyclopropylamine is refluxed for 45 minutes. After cooling, approximately 30 ml. of water is added. The reaction mixture is extracted three times with chloroform. The extracts are combined and dried over magnesium sulfate. The solvent is removed under reduced pressure. The residue is recrystallized twice from ethyl acetate/hexane to give N-cyclopropyl-2-(2-pyridyl)thioacetamide.
Aufarbeitung
- temperatureAfter cooling
- extractionThe reaction mixture is extracted three times with chloroform
- dry with materialdried over magnesium sulfate
- customThe solvent is removed under reduced pressure
- customThe residue is recrystallized twice from ethyl acetate/hexane
Quellen und Nachweise
- ORD-Eintrag
- ord-b8e087a1b0034817b66b7ed1f0a7b354
- Quelldatensatz
- uspto-grants-1978_10
- Patentnummer
- US04118567
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