Water → 2-[(1-Benzothien-4-yloxy)ethyl]morpholine

HRID 11427

Reaktionsgleichung

Reaktionsgleichung von HRID 11427
Cl.ClCC[N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.[S:11]1[C:15]2=[CH:16][CH:17]=[CH:18][C:19](O)=[C:14]2[CH:13]=[CH:12]1.[C:21](=[O:24])([O-])[O-].[K+].[K+].O.[CH3:28]N(C)C=O>>[S:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[C:19]([O:24][CH2:21][CH2:28][CH:9]3[O:8][CH2:7][CH2:6][NH:5][CH2:10]3)[C:14]=2[CH:13]=[CH:12]1

Komponenten

6

Edukt 5

HCID 962WaterHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 19217Benzo(b)thiophen-4-olHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

Produkt 1

HCID 867602232-[(1-Benzothien-4-yloxy)ethyl]morpholine

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionextracted twice with ethyl acetate
  3. washThe combined solvent phase was washed twice with brine
  4. dry with materialdried (magnesium sulphate)
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-2afdbf5b452c4473aa1f7b3a5c5a3a04
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098240B2

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