Sodium Hydroxide → 2-Aminobenzyl alcohol

HRID 1155331

Reaktionsgleichung

Reaktionsgleichung von HRID 1155331
O=C1[NH:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[CH2:4][O:3]1.[OH-].[Na+]>C(OC(C)C)(=O)C.O>[NH2:7][C:6]1[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=1[CH2:4][OH:3]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 257861,4-Dihydro-2H-3,1-benzoxazin-2-one

Produkt 1

HCID 214392-Aminobenzyl alcohol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 7915Isopropyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

The reaction mixture from Stage A was boiled so as to drive off the isopropyl acetate solvent. A solution of 100 g of sodium hydroxide in 100 ml of water was added to the residue, and the whole was refluxed for 2 hours. After cooling to 45° C., the product was extracted with four 270 ml portions of isopropyl acetate. The isopropyl acetate was then distilled off and the product recrystallized from toluene to give 100 g (63% of theoretical) of 97-98% pure 2-amino-benzyl alcohol; m.p. 83°-83.5° C.

Aufarbeitung

  1. temperaturethe whole was refluxed for 2 hours
  2. extractionthe product was extracted with four 270 ml portions of isopropyl acetate
  3. distillationThe isopropyl acetate was then distilled off
  4. customthe product recrystallized from toluene

Quellen und Nachweise

ORD-Eintrag
ord-caa27b79386f449a895ea5d3d2f83872
Quelldatensatz
uspto-grants-1981_11
Patentnummer
US04301283

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