Mescaline → 2-Formyl-3,4,5-trimethoxy-phenylethylamine

HRID 1155502

Reaktionsgleichung

Reaktionsgleichung von HRID 1155502
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][CH2:14][NH2:15])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[C:16](OC(=O)C)(=[O:18])C>C(O)=O>[CH:16]([CH:13]([C:5]1[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)[CH2:14][NH2:15])=[O:18]

Komponenten

4

Edukt 2

HCID 4076MescalineHCID 7918Acetic Anhydride

Produkt 1

HCID 867381162-Formyl-3,4,5-trimethoxy-phenylethylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

1.422 kg of 3,4,5-trimethoxy-phenylethylamine is slowly added to a mixture of 2.185 kg of 98% formic acid and 1.728 kg of acetic anhydride, while maintaining the temperature at about 50°. The reaction bath is maintained at this temperature for about 3 hours and the formic acid and acetic acid mixture and the excess anhydride is distilled. The formylated derivative thus obtained (1.734 kg) is used unpurified.

Aufarbeitung

  1. temperaturewhile maintaining the temperature at about 50°
  2. temperatureThe reaction bath is maintained at this temperature for about 3 hours
  3. distillationthe formic acid and acetic acid mixture and the excess anhydride is distilled
  4. customThe formylated derivative thus obtained (1.734 kg)

Quellen und Nachweise

ORD-Eintrag
ord-19c0d8cc26114b74b636f14f770ebde7
Quelldatensatz
uspto-grants-1981_11
Patentnummer
US04302458

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