Methanol → 3-[2-(2-Cyano-3-methylguanidino)-ethylsulphinylmethyl]-5-guanidino-1,2,4-thiadiazole

HRID 1155778Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1155778
[C:1]([N:3]=[C:4]([NH:19][CH3:20])[NH:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[N:14]=[C:13]([NH:15][C:16]([NH2:18])=[NH:17])[S:12][N:11]=1)#[N:2].I([O-])(=O)(=O)=[O:22].[Na+].CO>O>[C:1]([N:3]=[C:4]([NH:19][CH3:20])[NH:5][CH2:6][CH2:7][S:8]([CH2:9][C:10]1[N:14]=[C:13]([NH:15][C:16]([NH2:18])=[NH:17])[S:12][N:11]=1)=[O:22])#[N:2]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 23667635Sodium periodateHCID 178485071HCID 178485071, Verbindung

Produkt 1

HCID 1784850733-[2-(2-Cyano-3-methylguanidino)-ethylsulphinylmethyl]-5-guanidino-1,2,4-thiadiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 3-[2-(2-cyano-3-methylguanidino)-ethylthiomethyl]-5-guanidino-1,2,4-thiadiazole (0.626 g.), sodium metaperiodate (0.428 g.), methanol (20 ml.) and water (70 ml.) was stirred overnight at room temperature. The reaction mixture was evaporated to dryness and the residue extracted with absolute ethanol (120 ml.). The extract was filtered and evaporated to dryness. The residue was crystallised from methanol (with charcoal treatment) to give 3-[2-(2-cyano-3-methylguanidino)-ethylsulphinylmethyl]-5-guanidino-1,2,4-thiadiazole as a white powder, m.p. 185°-186°.

Aufarbeitung

  1. customThe reaction mixture was evaporated to dryness
  2. extractionthe residue extracted with absolute ethanol (120 ml.)
  3. filtrationThe extract was filtered
  4. customevaporated to dryness
  5. customThe residue was crystallised from methanol (with charcoal treatment)

Quellen und Nachweise

ORD-Eintrag
ord-9cbde29e005c45d49513d51444c12fed
Quelldatensatz
uspto-grants-1982_06
Patentnummer
US04332949

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