[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[C:13](CC#N)[C:12]=3[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1.[C:21]([OH:24])(=[O:23])[CH3:22].S(=O)(=O)(O)O.[OH-].[Na+]>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[C:13]([CH2:22][C:21]([OH:24])=[O:23])[C:12]=3[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1A mixture of 7.5 g of 1-(4-bromophenyl)isoquinoline-5-acetonitrile, 70 ml of acetic acid and 35 ml of 50% sulfuric acid was heated with stirring for 3 hours. After the reaction, water was added, and the pH of the reaction mixture was adjusted to 2 with an aqueous solution of sodium hydroxide. The crystals that precipitated were collected by filtration, and recrystallized from tetrahydrofuran-acetone to afford 7.0 g of 1-(4-bromophenyl)isoquinoline-5-acetic acid having a melting point of 230.5° to 232.5° C.
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