1,1'-Biphenyl, 3-nitro- → 3-Aminobiphenyl

HRID 1158191

Reaktionsgleichung

Reaktionsgleichung von HRID 1158191
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 1

HCID 164501,1'-Biphenyl, 3-nitro-

Produkt 1

HCID 167173-AminobiphenylAusbeute 77,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

3-nitrobiphenyl (500 mg, 2.5 mmol) and 10% palladium on carbon (267 mg, 2.5 mmol) were dissolved in methanol (1 mL) and purged with nitrogen and placed under an atmosphere of hydrogen overnight. The reaction mixture was filtered and evaporated to yield 326 mg of the desired amine, which was used directly in Example 12.

Aufarbeitung

  1. custompurged with nitrogen
  2. filtrationThe reaction mixture was filtered
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-fb8eac53c5df4318868e93e72310194f
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07807713B2

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