Hydrochloric Acid → 1-(3-Chloro-2,4-dihydroxy-phenyl)ethanone

HRID 1161021

Reaktionsgleichung

Reaktionsgleichung von HRID 1161021
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]([OH:11])=[CH:8][C:9]=1[OH:10])=[O:3].[OH-].[Na+].[Cl:14][O-].[Na+].Cl>O>[Cl:14][C:8]1[C:9]([OH:10])=[C:4]([C:2](=[O:3])[CH3:1])[CH:5]=[CH:6][C:7]=1[OH:11]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 69902',4'-DihydroxyacetophenoneHCID 14798Sodium HydroxideHCID 23665760Sodium Hypochlorite

Produkt 1

HCID 574382941-(3-Chloro-2,4-dihydroxy-phenyl)ethanoneAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 2,4-dihydroxyacetophenone (6 g, 39.4 mmol), aqueous 1M sodium hydroxide (41.4 mL, 41.4 mmol) and water (200 mL) is stirred at room temperature. An aqueous 1.6M solution of sodium hypochlorite (32 mL) is added over a 1 hr period. The resulting dark brown solution is stirred 18 hr at room temperature. The reaction mixture is adjusted to a pH of 2-3 with concentrated aqueous hydrochloric acid. The resulting suspension is filtered and washed with water (4×100 mL). The filtered solid was dried under vacuum at 45° C. for 2.5 days to give the title compound (4.8 g, 65%) as a brown solid. LCMS 1 187 M+.

Aufarbeitung

  1. filtrationThe resulting suspension is filtered
  2. washwashed with water (4×100 mL)
  3. customThe filtered solid was dried under vacuum at 45° C. for 2.5 days

Quellen und Nachweise

ORD-Eintrag
ord-c6985bac739c4f40be1b9f741ad7ff3b
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07816523B2

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