Water → 7-chloro-6-fluoro-1-(5-fluoro-pyridin-2-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic Acid

HRID 1163331Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1163331
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[CH:10][C:11]([Cl:18])=[C:12]([F:17])[CH:13]=2)[N:8]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][N:20]=2)[CH:7]=1)=[O:5])C.O>C(O)(=O)C.Cl>[Cl:18][C:11]1[CH:10]=[C:9]2[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]2[C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][N:20]=2)=[CH:13][C:12]=1[F:17]

Komponenten

5

Edukt 2

HCID 962WaterHCID 67274049HCID 67274049, Verbindung

Produkt 1

HCID 672739937-chloro-6-fluoro-1-(5-fluoro-pyridin-2-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic Acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 313Hydrochloric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A suspension of 0.5 g 7-chloro-6-fluoro-1-(5-fluoro-pyridin-2-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (1.37 mmol) in a mixture of 1.5 ml acetic acid and 1.5 ml 25% HCl was stirred at 90° C. over night. The reaction was monitored by HPLC. The suspension was poured into 50 ml water, the colorless crystals filtered and dried.

Aufarbeitung

  1. filtrationthe colorless crystals filtered
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6673dc493cf14f4fb829125619d9ed68
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07820823B2

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