Traboxopine → HCID 14555943, Verbindung

HRID 1164786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1164786
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]2[O:6][CH2:7][O:8][C:9]3[CH:22]=[CH:21][CH:20]=[CH:19][C:10]=3[N:11]([CH2:12][CH:13]([CH3:18])[CH2:14][N:15]([CH3:17])[CH3:16])[C:4]=2[CH:3]=1.[C:25]([OH:34])(=[O:33])[C@@H:26]([C@H:28]([C:30]([OH:32])=[O:31])[OH:29])[OH:27]>O>[C:30]([C@@H:28]([C@H:26]([C:25]([OH:34])=[O:33])[OH:27])[OH:29])([OH:32])=[O:31].[Cl:1][C:2]1[CH:24]=[CH:23][C:5]2[O:6][CH2:7][O:8][C:9]3[CH:22]=[CH:21][CH:20]=[CH:19][C:10]=3[N:11]([CH2:12][CH:13]([CH3:18])[CH2:14][N:15]([CH3:17])[CH3:16])[C:4]=2[CH:3]=1

Komponenten

4

Edukt 2

HCID 129812TraboxopineHCID 444305L-Tartaric acid

Produkt 1

HCID 14555943HCID 14555943, VerbindungAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

From the dichloromethane filtrate obtained in Example 3, section (A), the base is deliberated by the method of Example 1, section (B). To the residual syrup weighing 21.5 g, 9.3 g 0.063 moles of L(+)-tartaric acid are added in 85 CM3 of water. At first, a solution is obtained that is stirred for several hours. The (-)-base L(+)-tartrate precipitated is filtered, suspended in cold water, then filtered, suspended and filtered again. Thus, 17.5 g (70.0%) of (-)-2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxazocine L(+)-tartrate are obtained, m.p.: 109°-114° C.

Aufarbeitung

  1. customAt first, a solution is obtained
  2. customThe (-)-base L(+)-tartrate precipitated
  3. filtrationis filtered
  4. filtrationfiltered
  5. filtrationfiltered again

Quellen und Nachweise

ORD-Eintrag
ord-fce6a8337c934c9db4592a39aa34f74f
Quelldatensatz
uspto-grants-1990_03
Patentnummer
US04906622

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