Propargyl alcohol → Butane, 1-bromo-4-(2-propynyloxy)-

A mixture of 2-propyn-1-ol (10 g), 1,4-dibromobutane (60 ml), 50% aqueous sodium hydroxide (60 ml) and TAB (2 g) was stirred vigorously overnight. Water (250 ml) was added and the mixture was extracted with ether (2×200 ml). The organic extracts were dried and concentrated to a yellow oil which was purified by FCC eluting with H→H/ER (19:1) to give the title compound as a colourless oil (19.7 g), t.l.c. (H-ER 19:1) Rf 0.37.

1. extractionthe mixture was extracted with ether (2×200 ml)
2. customThe organic extracts were dried
3. concentrationconcentrated to a yellow oil which
4. customwas purified by FCC
5. washeluting with H→H/ER (19:1)

ORD-Eintrag

ord-a6cdcdb147434c73849d3f81192984d0

Quelldatensatz

uspto-grants-1990_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04908386