[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].C(=O)([O-])[O-].[Na+].[Na+].[Br:13][C:14]1([C:17](Cl)=[O:18])[CH2:16][CH2:15]1.[OH-].[Na+]>O.C(Cl)Cl>[CH3:5][C:2]([NH:1][C:17]([C:14]1([Br:13])[CH2:16][CH2:15]1)=[O:18])([CH3:6])[CH2:3][OH:4]
1.69 g of 2-amino-2-methyl-1-propanol is introduced into 85 ml of methylene chloride under nitrogen at room temperature, and 2.38 g of sodium carbonate is added to 38 ml of water and then 3.6 g of acid chloride 107. It is stirred overnight at room temperature and then treated with methanolic 2N sodium hydroxide solution. The organic phase is separated, dried on sodium sulfate and concentrated by evaporation. The residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 3.83 g of 1-bromocyclopropanecarboxylic acid-1,1-dimethyl-2-hydroxy-ethylamide 108 is obtained as a colorless oil.
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