Allyltributylstannane → 5-allyl-2,2-dimethyl-benzo[1,3]dioxin-4-one

HRID 1167198Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1167198
[CH3:1][C:2]1([CH3:20])[O:7][C:6](=[O:8])[C:5]2[C:9](S(C(F)(F)F)(=O)=O)=[CH:10][CH:11]=[CH:12][C:4]=2[O:3]1.[Li+].[Cl-].[CH2:23]([Sn](CCCC)(CCCC)CCCC)[CH:24]=[CH2:25].[F-].[K+]>CC1CNC(=O)C1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].O1C=CC=C1P(C1OC=CC=1)C1OC=CC=1>[CH2:25]([C:9]1[C:5]2[C:6](=[O:8])[O:7][C:2]([CH3:20])([CH3:1])[O:3][C:4]=2[CH:12]=[CH:11][CH:10]=1)[CH:24]=[CH2:23]

Komponenten

8

Edukt 4

HCID 90628AllyltributylstannaneHCID 433294Lithium ChlorideHCID 522689Potassium FluorideHCID 22336191HCID 22336191, Verbindung

Produkt 1

HCID 111486725-allyl-2,2-dimethyl-benzo[1,3]dioxin-4-oneAusbeute 97,2 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 521585Tris(furan-2-yl)phosphaneKatalysatorHCID 9811564Bis(dibenzylideneacetone)palladiumKatalysatorHCID 5339204-Methyl-2-pyrrolidinoneLösungsmittel

Versuchsvorschrift

To a stirred suspension of 2,2-dimethyl-5-(trifluoromethanesulfonyl)-benzo[1,3]dioxin-4-one (iii) (2.0 g, 6.13 mmol), anhydrous LiCl (0.8 g, 18.4 mmol), Pd2(dba)3 (112 mg, 0.12 mmol), and tri-(2-furyl)phosphine (115 mg, 0.49 mmol) in 4-methyl-2-pyrrolidinone (10 mL) was added allyltributyltin (2.35 mL, 7.36 mmol). After stirring for 48 h at rt, saturated aqueous KF (20 mL) was added and an extraction was performed with Et2O (3×). The combined organics were dried over MgSO4, concentrated in vacuo and the residue was purified by FC (4% EtOAc/hexanes) to give 1.3 g of 5-allyl-2,2-dimethyl-benzo[1,3]dioxin-4-one (iv) which was slightly impure.

Aufarbeitung

  1. extractionan extraction
  2. dry with materialThe combined organics were dried over MgSO4
  3. concentrationconcentrated in vacuo
  4. customthe residue was purified by FC (4% EtOAc/hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-292719cb67064e08b75627bbccff94f5
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06617348B1

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