Bromine → 2-Amino-3-bromo-5-methylbenzoic acid

HRID 1169977

Reaktionsgleichung

Reaktionsgleichung von HRID 1169977
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br>C(O)(=O)C>[NH2:1][C:2]1[C:10]([Br:12])=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 762552-Amino-5-methylbenzoic acid

Produkt 1

HCID 27744002-Amino-3-bromo-5-methylbenzoic acidAusbeute 85,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 2-amino-5-methylbenzoic acid (25.0 g, 170 mmol) in acetic acid (250 ml) was added bromine (10 ml, 195 mmol) and the reaction mixture was stirred at room temperature for 2 h. The mixture was filtered and the solid material was washed with water and cyclohexane and dried to give the title compound (33.4 g).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. washthe solid material was washed with water and cyclohexane
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5679cf46e3e942f5892e452b3773d499
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07825149B2

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