Stannous Chloride → 2-Amino-5-fluorobenzonitrile

HRID 1169985

Reaktionsgleichung

Reaktionsgleichung von HRID 1169985
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]#[N:12])([O-])=O.Cl[Sn]Cl>Cl>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]#[N:12]

Komponenten

4

Edukt 2

HCID 24479Stannous ChlorideHCID 37564675-Fluoro-2-nitrobenzonitrile

Produkt 1

HCID 27377042-Amino-5-fluorobenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

The title compound was synthesized from commercially available 2-nitro-5-fluorobenzenecarbonitrile via reduction with SnCl2 in concentrated HCl as previously described in the following reference which is herein incorporated by reference in its entirety for all purposes as if fully set forth herein: Hunziker, F. et al. Eur. J. Med. Chem., Chim. Ther. 1981, 16(5), 391. GC/MS m/z: 136.1 (M+, 100%), Rt 8.87 minutes.

Quellen und Nachweise

ORD-Eintrag
ord-01cbccf3425e409f9d5ffa2a1318af5c
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07825132B2

Verknüpfte Notizen

Wird geladen…