Bromine → 2-Bromo-1-[4-(4-chlorophenoxy)-2-propylphenyl]ethanone

HRID 1172812

Reaktionsgleichung

Reaktionsgleichung von HRID 1172812
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[C:9]([CH2:16][CH2:17][CH3:18])[CH:8]=2)=[CH:4][CH:3]=1.[Br:21]Br>O1CCOCC1.C(OCC)(=O)C>[Br:21][CH2:14][C:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][C:5]2[CH:19]=[CH:20][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:8][C:9]=1[CH2:16][CH2:17][CH3:18])=[O:15]

Komponenten

5

Edukt 2

HCID 24408BromineHCID 574201401-[4-(4-Chlorophenoxy)-2-propylphenyl]ethanone

Produkt 1

HCID 574201412-Bromo-1-[4-(4-chlorophenoxy)-2-propylphenyl]ethanone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8857Ethyl AcetateLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of the product from Step 7 (1.2 g, 4.2 mmol) in dioxane (20 mL) at room temperature was added dropwise bromine (0.25 mL, 5.0 mmol). After 2 h at room temperature, the reaction mixture was diluted with ethyl acetate, washed with an aqueous solution of sodium thiosulfate and dried over magnesium sulfate. Removal of the solvent gave a residue which was purified by chromatography on silica gel to give the title product.

Aufarbeitung

  1. washwashed with an aqueous solution of sodium thiosulfate
  2. dry with materialdried over magnesium sulfate
  3. customRemoval of the solvent
  4. customgave a residue which
  5. customwas purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-4a0aca9f0f9142fd82b0edbabff23fc3
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834036B2

Verknüpfte Notizen

Wird geladen…