Triethylamine → HCID 131728274, Verbindung

Temperatur

0 °C

To a solution of 6-hydroxymethyl-benzo[b]thiophene-2-carboxylic acid ethyl ester (2.52 g, 10.7 mmol) and triethylamine (3.00 mL, 21.5 mmol) in anhydrous THF (80 mL) at 0° C. was added methanesulfonyl chloride (1.24 mL, 16.0 mmol). The resulting mixture was allowed to stir at 0° C. for 30 min, diluted with EtOAc (400 mL), washed with saturated NaHCO3, water and brine. The organic layer was dried over Na2SO4. After filtration, the filtrate was concentrated and the residue was dissolved in anhydrous DMF (60 mL). After sodium azide (1.41 g, 21.6 mmol) was added, the mixture was heated at 50° C. for 30 min. After cooling to rt, the mixture was diluted with EtOAc (300 mL) and water (60 mL). The organic layer was further washed with water and brine, and then dried over Na2SO4. After filtration, the filtrate was concentrated and the residue was dissolved in THF (60 mL) and water (6 mL). Triphenylphosphine (3.64 g, 13.9 mmol) was added and the mixture was allowed to stir at rt overnight and then concentrated. The residue was dissolved in ether (400 mL) and 4M HCl in dioxane (6 mL) was added dropwise. The solid formed was washed with ether (5×30 mL) and dried to give 6-aminomethyl-benzo[b]thiophene-2-carboxylic acid ethyl ester, hydrochloride salt as a pale solid. 1H NMR (DMSO-d6, 200 MHz) δ 8.66 (brs, 2H), 8.24-8.10 (m, 2H), 8.06 (d, J=8.6 Hz, 1H), 7.62 (dd, J=8.4, 1.6 Hz, 1H), 4.34 (q, J=7.4 Hz, 2H), 4.13 (s, 2H), 1.32 (t, J=7.0 Hz, 3H). MS (EI): cal'd 236.1 (MH+), exp 236.1 (MH+).

1. washwashed with saturated NaHCO3, water and brine
2. dry with materialThe organic layer was dried over Na2SO4
3. filtrationAfter filtration
4. concentrationthe filtrate was concentrated
5. dissolutionthe residue was dissolved in anhydrous DMF (60 mL)
6. temperaturethe mixture was heated at 50° C. for 30 min
7. temperatureAfter cooling to rt
8. washThe organic layer was further washed with water and brine
9. dry with materialdried over Na2SO4
10. filtrationAfter filtration
11. concentrationthe filtrate was concentrated
12. dissolutionthe residue was dissolved in THF (60 mL)
13. stirringto stir at rt overnight
14. concentrationconcentrated
15. dissolutionThe residue was dissolved in ether (400 mL)
16. addition4M HCl in dioxane (6 mL) was added dropwise
17. customThe solid formed
18. washwas washed with ether (5×30 mL)
19. customdried

ORD-Eintrag

ord-2fa0b9bae55e415fbf3952c868e088cb

Quelldatensatz

uspto-grants-2010_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07834034B2