2,4-Diamino-6-ethoxypyrimidine → 6-Ethoxy-5-nitrosopyrimidine-2,4-diamine

HRID 1178218Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1178218
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][CH3:10])[CH:5]=[C:4]([NH2:11])[N:3]=1.[N:12]([O-])=[O:13].[Na+]>C(O)(=O)C.O>[N:12]([C:5]1[C:6]([O:8][CH2:9][CH3:10])=[N:7][C:2]([NH2:1])=[N:3][C:4]=1[NH2:11])=[O:13]

Komponenten

5

Edukt 2

HCID 2226632,4-Diamino-6-ethoxypyrimidineHCID 23668193Sodium Nitrite

Produkt 1

HCID 2272506-Ethoxy-5-nitrosopyrimidine-2,4-diamineAusbeute 68,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of the compound of example 54 (6.13 g, 39.8 mmoles) in 20% aqueous acetic acid (57 ml) was added dropwise a solution of NaNO2 (3.29 g) in water (13 ml) at 80° C. A pink precipitate was formed which was stirred at 80° C. for an additional 2 hours. The reaction mixture was cooled down in the refrigerator overnight and the resulting precipitate was filtered off, yielding the title compound as a pink powder (4.98 g, yield 68%). Spectral data are identical with those described e.g. by W. Pfleiderer et al. in Chem. Ber. (1961) 94, 12.

Aufarbeitung

  1. customA pink precipitate was formed which
  2. temperatureThe reaction mixture was cooled down in the refrigerator overnight
  3. filtrationthe resulting precipitate was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-b51ac65faca143009dc86180aea0013a
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07276506B2

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