Hydrochloric Acid → [3-(4-{[(phenylamino)carbonyl]amino}phenyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]acetic acid

Temperatur

70 °C

A heterogeneous mixture of [3-(4-nitrophenyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]acetic acid (31.0 mmol), elemental tin dust (5.30 mmol), 6.0N aqueous hydrochloric acid (5.3 mL) and absolute ethanol (5.3 mL) was stirred at 70° C. for 1 h. The solution was filtered through Celite and concentrated in vacuo. The resulting aniline was dissolved in anhydrous pyridine (10 mL) and phenyl isocyanate (11.17 mmol) added dropwise. The reaction mixture was stirred at room temperature for 4 h. After concentration in vacuo, purification by Gilson reverse phase HPLC afforded the title compound as a white solid (93%). ESMS [M+H]+: 453.2

1. filtrationThe solution was filtered through Celite
2. concentrationconcentrated in vacuo
3. dissolutionThe resulting aniline was dissolved in anhydrous pyridine (10 mL)
4. stirringThe reaction mixture was stirred at room temperature for 4 h
5. concentrationAfter concentration
6. customin vacuo, purification by Gilson reverse phase HPLC

ORD-Eintrag

ord-9358a108a1fb42f3ace8d25a6270a994

Quelldatensatz

uspto-grants-2007_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07282588B2