Water → 2-Methoxy-4-(trifluoromethyl)benzonitrile

HRID 1181424

Reaktionsgleichung

Reaktionsgleichung von HRID 1181424
[N+]([C:4]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7])([O-])=O.[CH3:16][O-:17].[Na+].O>CO>[CH3:16][O:17][C:4]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

Komponenten

5

Edukt 3

HCID 962WaterHCID 699022-Nitro-4-(trifluoromethyl)benzonitrileHCID 10942334Sodium Methoxide

Produkt 1

HCID 190013762-Methoxy-4-(trifluoromethyl)benzonitrileAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To a solution of 2-nitro-4-(trifluoromethyl)benzonitrile (22.48 g, 104 mmol) in anhydrous methanol (110 ml) was added dropwise 25% sodium methoxide in methanol (24.72 ml, 114.4 mmol), and the resulting mixture stirred at room temperature for 1 hour. Water (110 ml) was added and the resulting solids collected by filtration. The solids were dissolved in DCM (150 ml), washed with sat NaCl (75 ml), dried over Na2SO4, filtered and evaporated to give the title compound (19 g, 91%) as a white solid.

Aufarbeitung

  1. filtrationthe resulting solids collected by filtration
  2. dissolutionThe solids were dissolved in DCM (150 ml)
  3. washwashed with sat NaCl (75 ml)
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-c429fac802f345ae93bd22b24c07a7e3
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07285563B2

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