Bromine → N-(3-Bromo-4-oxocyclohexyl)acetamide

HRID 1181630Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1181630
NC1SC2CC(N)CCC=2N=1.[Br:12]Br.[C:14]([NH:17][CH:18]1[CH2:23][CH2:22][C:21](=[O:24])[CH2:20][CH2:19]1)(=[O:16])[CH3:15]>O>[Br:12][CH:22]1[CH2:23][CH:18]([NH:17][C:14](=[O:16])[CH3:15])[CH2:19][CH2:20][C:21]1=[O:24]

Komponenten

5

Edukt 3

HCID 24408BromineHCID 538565N-(4-Oxocyclohexyl)acetamideHCID 103297212,6-Diamino-4,5,6,7-tetrahydrobenzothiazole

Produkt 1

HCID 58981395N-(3-Bromo-4-oxocyclohexyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

According to one aspect of the present invention there is provided a method of synthesising 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole, which method comprises comprising: (i) reacting bromine with a solution of 4-acetamido-cyclohexanone in water to produce 2-bromo-4-acetamido-cyclohexanone; (ii) after step (i), adding thiourea to produce 6-acetylamino-2-amino4,5,6,7-tetrahydro-benzthiazole-dihydrobromide; (iii) after step (ii), adding an aqueous solution of hydrobromic acid to produce 2,6-diamino-4,5,6,7-tetrahydro-benzthiazole; and (iv) after step (iii), isolating 2,6-diamino-4,5,6,7-tetrahydro-benzthiazole free base.

Aufarbeitung

  1. customis provided

Quellen und Nachweise

ORD-Eintrag
ord-336a809a92884ed69b31809130ebf144
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07285669B2

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