Morpholine → 4-(2-Fluoro-4-nitrophenyl)morpholine

HRID 1181954Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1181954
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.C(N(CC)C(C)C)(C)C>C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Komponenten

5

Edukt 3

HCID 8083MorpholineHCID 81531DiisopropylethylamineHCID 1230531,2-Difluoro-4-nitrobenzene

Produkt 1

HCID 29054894-(2-Fluoro-4-nitrophenyl)morpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

3,4-Difluoronitrobenzene (3.7 g, 23.2 mmol) was dissolved in ethyl acetate (10 mL). Morpholine (2.2 mL, 25 mmol), and N,N-diisopropylethylamine (4 mL, 23 mmol) were added and the mixture stirred overnight at room temperature. At 17 h, additional ethyl acetate (150 mL) was added and the combined mixture was washed with water (50 mL) and brine (50 mL), dried (Na2SO4), filtered and concentrated under vacuum. The residue was used without further purification.

Aufarbeitung

  1. waitAt 17 h
  2. washthe combined mixture was washed with water (50 mL) and brine (50 mL)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum
  6. customThe residue was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-b325d870388f4482bdf34a4be2872dc8
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07285662B2

Notizen zur Reaktion

Wird geladen…