Lithium hydroxide, monohydrate → lithium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

HRID 1183132

Reaktionsgleichung

Reaktionsgleichung von HRID 1183132
C[O:2][C:3]([C@H:5]1[CH2:9][O:8][C:7]([CH3:11])([CH3:10])[O:6]1)=[O:4].O.[OH-].[Li+:14]>CO.O>[CH3:10][C:7]1([CH3:11])[O:6][C@@H:5]([C:3]([O-:4])=[O:2])[CH2:9][O:8]1.[Li+:14]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 853166Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

Produkt 1

HCID 67153178lithium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylateAusbeute 96,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid methyl ester (5.0 g, 31.25 mmol) in MeOH (32.0 mL) at room temperature was added a solution of lithium hydroxide monohydrate (1.31 g, 31.25 mmol) in water (10.0 mL). The resulting mixture was stirred for thirty min before it was concentrated. The resulting white solid was further dried under vacuum to give the title compound (4.59 g).

Aufarbeitung

  1. concentrationwas concentrated
  2. customThe resulting white solid was further dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e01dfab223d24d8a9e41c14703c29e50
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08664242B2

Verknüpfte Notizen

Wird geladen…