1,2-Dichloroethane → HCID 178452378, Verbindung

HRID 1185541Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1185541
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH3:13])=[C:9]([CH3:12])[CH:10]=2)[N:5]=[C:4]([C:14]([OH:16])=O)[CH:3]=1.[CH2:17]([O:21][C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30](=[O:33])[CH2:31][NH2:32])[CH2:26][CH2:25]1)=[O:23])[CH2:18][CH2:19][CH3:20].C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl>CN(C=O)C.O>[CH2:17]([O:21][C:22]([N:24]1[CH2:25][CH2:26][N:27]([C:30](=[O:33])[CH2:31][NH:32][C:14]([C:4]2[CH:3]=[C:2]([OH:1])[C:11]3[C:6](=[CH:7][C:8]([CH3:13])=[C:9]([CH3:12])[CH:10]=3)[N:5]=2)=[O:16])[CH2:28][CH2:29]1)=[O:23])[CH2:18][CH2:19][CH3:20]

Komponenten

7

Edukt 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 667130634-(2-Amino-acetyl)-piperazine-1-carboxylic acid butyl esterHCID 178422310HCID 178422310, Verbindung

Produkt 1

HCID 178452378HCID 178452378, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 100 mg of 4-Hydroxy-6,7-dimethyl-quinoline-2-carboxylic acid and 164 mg of 4-(2-Amino-acetyl)-piperazine-1-carboxylic acid butyl ester in 1 ml of DMF, 70 mg of HOBT and 88 mg of EDC was added and the reaction mixture was stirred for 4 h at RT. Then, the reaction mixture was diluted with water and filtered through a chem Elut® cartridge by eluting with ethyl acetate. The solvents were removed under reduced pressure and the isolated crude product was pure enough for the next reaction step. Yield: 250 mg.

Aufarbeitung

  1. filtrationfiltered through a chem Elut® cartridge
  2. washby eluting with ethyl acetate
  3. customThe solvents were removed under reduced pressure
  4. customthe isolated crude product
  5. customwas pure enough for the next reaction step

Quellen und Nachweise

ORD-Eintrag
ord-b9820dab69e64761a41dc968d6d6b3a0
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08669266B2

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