Dichloromethane → (4-Aminopyrimidin-5-yl)boronic acid

Temperatur

105 °C

To a vial was added 5-bromopyrimidin-4-amine (0.200 g, 1.149 mmol), bis(pinacolato)diboron (0.438 g, 1.724 mmol), and potassium acetate (0.338 g, 3.45 mmol). The vial was capped with a rubber septum and then evacuated and backfilled with N2. Dioxane (0.120 ml) was added via syringe through the septum. The reaction mixture was sparged with N2, then PdCl2(dppf).CH2Cl2 (0.042 g, 0.057 mmol) was added. The septum was then replaced with a Teflon screw valve and the vial was sealed. The reaction mixture was heated at 105° C. in a metal pie block. After 18 h, reaction mixture was allowed to cool to room temperature. The reaction mixture was filtered through a disposable fritted funnel and the filter cake washed with EtOAc. The filtrate was concentrated to afford a brown solid. MS (ESI): m/z=140.0 [M+H]+ HPLC Peak ret. T=0.24 minutes was product (HPLC conditions: Column:Luna C18 4.6×30 mm 3 u A:10:90 H2O:ACN NH4OAc/B:10:90 H2O:ACN NH4OAc; 0%-95% B in 2 min; 4 mL/min flow).

1. customThe vial was capped with a rubber septum
2. customevacuated
3. additionDioxane (0.120 ml) was added via syringe through the septum
4. customThe reaction mixture was sparged with N2
5. customthe vial was sealed
6. customreaction mixture
7. temperatureto cool to room temperature
8. filtrationThe reaction mixture was filtered through a disposable fritted funnel
9. washthe filter cake washed with EtOAc
10. concentrationThe filtrate was concentrated
11. customto afford a brown solid
12. customT=0.24 minutes
13. wait0%-95% B in 2 min

ORD-Eintrag

ord-fdcb3b65004f47d9810cc4dc93cf0d40

Quelldatensatz

uspto-grants-2014_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08673922B2