Formamide → 6-Chloroquinazolin-4-amine

HRID 1187255

Reaktionsgleichung

Reaktionsgleichung von HRID 1187255
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[C:4]#[N:5].O.[CH:12]([NH2:14])=O>>[NH2:5][C:4]1[C:3]2[C:2](=[CH:9][CH:8]=[C:7]([Cl:10])[CH:6]=2)[N:1]=[CH:12][N:14]=1

Komponenten

4

Edukt 3

HCID 713FormamideHCID 962WaterHCID 800192-Amino-5-chlorobenzonitrile

Produkt 1

HCID 3202476-Chloroquinazolin-4-amineAusbeute 95 %

Versuchsvorschrift

A solution of 2-amino-5-chlorobenzonitrile (1.07 g, 7.0 mmol) in formamide (20 ml) was heated at 180° C. for 6 hours. After cooling to room temperature, water (30 ml) was added to the reaction mixture. The precipitate was collected by filtration, washed with water and dried over P2O5, yielding the title compound as a grey solid (1.2 g, yield: 95%) which was characterized by its mass spectrum as follows: MS (m/z): 180 ([M+H]+, 100).

Aufarbeitung

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water
  3. dry with materialdried over P2O5

Quellen und Nachweise

ORD-Eintrag
ord-adf704e9d21d4fca9b488f33b293ef1e
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673929B2

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